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Using Experimental Means To Have Children

 The WBAL Channel March 15, 2004
 

DETROIT -- Couples who have trouble conceiving often go to great lengths in hopes of having a child. When in-vitro procedures don't work, some turn to experimental treatments.

 

Sharon and Paul Saarinen say 3-year-old Alana is their dream come true. But, after 10 years and 4 failed invitro fertlization attempts that dream was once a nightmare.

 

"We went through some tough times," Paul said. "It was really tearing our marriage apart."

 

 

"I was willing to do whatever it took," Sharon said. "I had to have a baby. I didn't feel complete."

 

Sharon was told she was premenopausal and her eggs were not vital enough to create a healthy embryo. Her doctor said there was nothing more he could do.

 

"It's so devastating, but in my heart I knew I was going to have a child," she said. "So I knew there had to be another option. I wouldn't accept no."

 

That option was with Dr. Michael Fakih, a fertility expert who was willing to try an experimental treatment called cytoplasmic transfer using Sharon's own eggs. Taking the cytoplasm from a healthy donor egg, he implanted it into Sharon's weaker egg to help it survive. Once it was fertilized, it was implanted in her uterus and she was pregnant.

 

The donor cytoplasm contains mitochondrial DNA which gives the egg that energy to survive, but it is not trait-related DNA.

 

Yet some doctors say the potential for birth defects still remains. If you have three people's DNA in one embryo, the concern is possible chromosomal abnormalities in the child.

 

Fakih says the donor eggs are carefully tested and adds all of the seven babies he's delivered from this procedure are healthy.

 

When the Saarinens decided they wanted to try and have another child, they returned to Fakih's clinic in suburban Detroit, only to be told that the FDA had sent letters to doctors informing them that cytoplasmic transfer and other so-called experimental procedures had been banned. The FDA said in order to proceed, rigorous testing would need to be done to get the agency's approval.

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